Publikacje naukowe

Zespół Instytutu łączy praktykę ekspercką z pracą naukową. Poniżej pełny wykaz prac indeksowanych w bazie PubMed, w których współautorami są specjaliści Instytutu — od opisów przypadków i opinii sądowych po metody analityczne dla nowych substancji psychoaktywnych.

Wykaz publikacji

1. 2026Forensic Toxicology

   '3-Trifluoromethylphenylpiperazine (TFMPP)' misidentification in aripiprazole-positive cases: a cautionary note

   Nowak K, Zawadzki M, Szpot P

2. 2026Metabolites

   4-Bromomethcathinone (4-BMC) Revisited: The First Reported Fatal Case and Toxicological Insights

   Nowak K, Szpot P, Zawadzki M, Chłopaś-Konowałek A

3. 2026International Journal of Molecular Sciences

   Analysis of the Efficacy of Acetylcholinesterase Inhibitors in the Treatment of Alzheimer's Disease, Literature Review

   Petrov W, Ślebioda D, Kozińska R, Kukla K, Petrov P, Sroka M, Tesyna J, Puźniak G, Kudliński M, Rejda T, Skowron I, Chłopaś-Konowałek A

4. 2026Forensic Science International

   Comparative stability assessment of designer benzodiazepines and methaqualones in dry blood spots and blood using UHPLC-MS/MS: Implications for forensic applications

   Tusiewicz K, Szpot P, Zawadzki M

5. 2026Forensic Toxicology

   Comparative stability assessment of novel LSD analogs in dry blood spots and blood using UHPLC-MS/MS: implications for forensic applications

   Tusiewicz K, Szpot P, Zawadzki M

6. 2026Toxicology Mechanisms and Methods

   Comparative stability assessment of synthetic cannabinoids in dry blood spots and blood using UHPLC-MS/MS: implications for forensic applications

   Tusiewicz K, Szpot P, Zawadzki M

7. 2026Journal of Xenobiotics

   Dual-Column HS-GC-FID/FID Method for In-Depth Analysis of Low-Molecular-Weight Volatile Alcohols in Postmortem Biological Material

   Szpot P, Wachełko O, Tusiewicz K, Zawadzki M

8. 2026Biomedicines

   Naltrexone and Nalmefene as Modern Psychopharmacotherapy for Alcohol Use Disorder: Modulation of Opioid Receptors and Neurobiological Pathways of Alcohol Action

   Rząca M, Sroka M, Fus K, Ślebioda D, Kozinska R, Chmiela M, Chłopaś-Konowałek A

9. 2026Advances in Clinical and Experimental Medicine

   Navigating medication adherence in chronic diseases

   Uchmanowicz I, Jędrzejczyk M, Jakubiak GK, Chłopaś-Konowałek A, Iovino P, Aldossary HM, Piwowar A, Uchmanowicz B, Lomper K, Gonos J, Jaros R, Sawczak F, Jaguszewski M, Kołtuniuk A

10. 2026Forensic Toxicology

    Reinventing quaaludes: a comprehensive review of designer methaqualone analogs

    Wachełko O, Tusiewicz K, Zawadzki M, Szpot P

11. 2026Molecules

    Safety and Efficacy of Natural and Conventional Psychiatric Treatments: A Comparative Review of Mushroom-Derived Compounds and Medicinal Plants in the Management of Mental Disorders

    Gawłowska K, Nowakowska KK, Makówka JW, Bajurny W, Góral MP, Bocheńska A, Kopecki SD, Grodzińska WM, Chłopaś-Konowałek A

12. 2025International Journal of Molecular Sciences

    A Fatal Case Involving Chronic Intravenous Use of Homemade Methcathinone Derived from Pseudoephedrine Tablets: Post-Mortem Concentrations, Health Risk, and Medicolegal Aspect

    Nowak K, Szpot P, Zawadzki M

13. 2025The Analyst

    A highly sensitive UHPLC-MS/MS method for determining 15 designer LSD analogs in biological samples with application to stability studies

    Wachełko O, Nowak K, Tusiewicz K, Zawadzki M, Szpot P

14. 2025Journal of Antimicrobial Chemotherapy

    Antibiotic stress affects the secretion and physicochemical features of extracellular vesicles produced by Helicobacter pylori

    Krzyżek P, Opalińska A, Migdał P, Tusiewicz K, Szpot P, Zawadzki M, Krzyżanowska B, Kulus MJ, Podhorska-Okołów M, Sobieszczańska B

15. 2025Forensic Toxicology

    Beware of misattributing 'modafinil' in diphenhydramine-positive cases

    Nowak K, Zawadzki M, Szpot P

16. 2025Journal of Controlled Release

    Engineering unnatural amino acids in peptide linkers enables cathepsin-selective antibody-drug conjugates for HER2-positive breast cancer

    Gorzeń O, Łęcka M, Ćwilichowska-Puślecka N, Majchrzak M, Horbach N, Wiśniewski J, Jakimowicz P, Szpot P, Zawadzki M, Dołęga-Kozierowski B, Kasprzak P, Turk B, Drąg M, Groborz KM, Matkowski R, Poręba M

17. 2025Toxicology Mechanisms and Methods

    From historical drugs to present perils: UHPLC-QqQ-MS/MS determination of methaqualone and its designer analogs (NPS) with comprehensive fragmentation pathways study (QTOF)

    Tusiewicz K, Wachełko O, Szpot P, Zawadzki M

18. 2025Journal of Clinical Medicine

    Holistic Management of Adult ADHD with a History of Addiction: Emphasis on Low-Addiction-Risk Psychopharmacotherapy

    Żełabowski K, Petrov W, Ślebioda D, Rusinek M, Biedka K, Błaszczyk K, Wesołowski M, Wojtysiak K, Sroka M, Ratka Z, Ilski I, Chłopaś-Konowałek A

19. 2025Journal of Clinical Medicine

    Lamotrigine Therapy: Relation Between Treatment of Bipolar Affective Disorder and Incidence of Stevens-Johnson Syndrome-A Narrative Review of the Existing Literature

    Żełabowski K, Wojtysiak K, Ratka Z, Biedka K, Chłopaś-Konowałek A

20. 2025Forensic Toxicology

    Method for determination of cytisine in post-mortem biological matrices and its application to two forensic cases

    Nowak K, Szpot P, Zawadzki M, Chłopaś-Konowałek A

21. 2025Pharmaceuticals

    Review of Selected 2-Phenylethylamine Derivatives and Opioids, Systematic Review of Their Effects on Psychomotor Abilities and Driving Performance: Psychopharmacology in the Context of Road Safety

    Żełabowski K, Biedka K, Pichowicz W, Sterkowicz M, Radzka I, Ilski I, Wesołowski M, Wojtysiak K, Petrov W, Ślebioda D, Rząca M, Chłopaś-Konowałek A

22. 2025Archiwum Medycyny Sądowej i Kryminologii

    Stability of acetylcholinesterase (AChE) activity in blood: the effect of the preservative agent

    Tusiewicz K, Szpot P, Wachełko O, Zawadzki M

23. 2025International Journal of Molecular Sciences

    Targeting the Orexin System in the Pharmacological Management of Insomnia and Other Diseases: Suvorexant, Lemborexant, Daridorexant, and Novel Experimental Agents

    Żełabowski K, Petrov W, Wojtysiak K, Ratka Z, Biedka K, Wesołowski M, Fus K, Ślebioda D, Rusinek M, Sterkowicz M, Radzka I, Chłopaś-Konowałek A

24. 2025Molecules

    The Efficacy of Melatonergic Receptor Agonists Used in Clinical Practice in Insomnia Treatment: Melatonin, Tasimelteon, Ramelteon, Agomelatine, and Selected Herbs

    Żełabowski K, Pichowicz W, Skowron I, Szwach J, Biedka K, Wesołowski M, Błaszczyk K, Ziobro O, Petrov W, Kukula-Koch W, Chłopaś-Konowałek A

25. 2025Journal of Xenobiotics

    The Issue of "Smart Drugs" on the Example of Modafinil: Toxicological Analysis of Evidences and Biological Samples

    Nowak K, Chłopaś-Konowałek A, Szpot P, Zawadzki M

26. 2025Journal of Pharmaceutical and Biomedical Analysis

    The UHPLC-MS/MS method for the determination of 26 synthetic benzimidazole opioids (nitazene analogs) with isomers separation

    Wachełko O, Tusiewicz K, Szpot P, Zawadzki M

27. 2024Molecules

    Application of UHPLC-QqQ-MS/MS Method for Quantification of Beta-Adrenergic Blocking Agents (β-Blockers) in Human Postmortem Specimens

    Szpot P, Tusiewicz K, Wachełko O, Zawadzki M

28. 2024Archiwum Medycyny Sądowej i Kryminologii

    Determination of cefuroxime in human blood and urine using UHPLC-MS/MS and its application to stability study of cefuroxime over 278 days

    Nowak K, Zawadzki M, Szpot P

29. 2024Archives of Toxicology

    Development of two ultra-sensitive UHPLC-QqQ-MS/MS methods for the simultaneous determination of hydroxyzine and its active metabolite (cetirizine) in human blood: applications to real cases of forensic toxicology

    Chłopaś-Konowałek A, Szpot P, Zawadzki M, Kukula-Koch W, Dudzińska E

30. 2024Molecules

    Forensic Aspects of Designer LSD Analogs Identification by GC-MS (EI) and UV Spectroscopy

    Tusiewicz K, Wachełko O, Zawadzki M, Szpot P

31. 2024Journal of Xenobiotics

    Novel Technique for Simultaneous Ethylene Glycol and Its Metabolites Determination in Human Whole Blood and Urine Samples Using GC-QqQ-MS/MS

    Tusiewicz K, Wachełko O, Zawadzki M, Szpot P

32. 2024Frontiers in Pharmacology

    Subinhibitory concentrations of antibiotics affect development and parameters of Helicobacter pylori biofilm

    Krzyżek P, Migdał P, Tusiewicz K, Zawadzki M, Szpot P

33. 2024Toxicology Mechanisms and Methods

    The stability of cyanide in human biological samples. A systematic review, meta-analysis and determination of cyanide (GC-QqQ-MS/MS) in an authentic casework 7 years after fatal intoxication

    Tusiewicz K, Wachełko O, Zawadzki M, Szpot P

34. 2023Journal of Forensic Sciences

    A fatal case involving the highest ever reported 4-CMC concentration

    Tusiewicz K, Chłopaś-Konowałek A, Wachełko O, Zawadzki M, Szpot P

35. 2023Human Psychopharmacology

    A narrative review of the neuropharmacology of synthetic cathinones-Popular alternatives to classical drugs of abuse

    Kuropka P, Zawadzki M, Szpot P

36. 2023Forensic Toxicology

    A review of synthetic cathinones emerging in recent years (2019-2022)

    Kuropka P, Zawadzki M, Szpot P

37. 2023Talanta

    An ultra-sensitive UHPLC-QqQ-MS/MS method for determination of 54 benzodiazepines (pharmaceutical drugs, NPS and metabolites) and z-drugs in biological samples

    Wachełko O, Szpot P, Tusiewicz K, Nowak K, Chłopaś-Konowałek A, Zawadzki M

38. 2023Toxics

    Determination of Prostaglandins (Carboprost, Cloprostenol, Dinoprost, Dinoprostone, Misoprostol, Sulprostone) by UHPLC-MS/MS in Toxicological Investigations

    Szpot P, Wachełko O, Zawadzki M

39. 2023Forensic Toxicology

    Emerging trends in methaqualone and analogues abuse: insights from online forums

    Kuropka P, Zawadzki M, Szpot P

40. 2023Forensic Toxicology

    Methyl (S)-2-(1-7 (5-fluoropentyl)-1H-indole-3-carboxamido)-3,3-dimethylbutanoate (5F-MDMB-PICA) intoxication in a child with identification of two new metabolites (ultra-high-performance liquid chromatography-tandem mass spectrometry)

    Szpot P, Nowak K, Wachełko O, Tusiewicz K, Chłopaś-Konowałek A, Zawadzki M

41. 2023Journal of Pharmaceutical and Biomedical Analysis

    New approach for barbiturates, phenytoin, methyprylon and glutethimide determination and fragmentation (UHPLC-MS/MS)

    Wachełko O, Tusiewicz K, Zawadzki M, Szpot P

42. 2023Toxics

    Nitrites: An Old Poison or a Current Hazard? Epidemiology of Intoxications Covering the Last 100 Years and Evaluation of Analytical Methods

    Tusiewicz K, Kuropka P, Workiewicz E, Wachełko O, Szpot P, Zawadzki M

43. 2023Archiwum Medycyny Sądowej i Kryminologii

    Review of the experiences of users of methaqualone and methaqualone derivatives. An analysis of online forums

    Kuropka P, Zawadzki M, Szpot P

44. 2022Toxics

    A Case of Amphetamine and Methamphetamine Intoxication in Cat

    Chłopaś-Konowałek A, Tusiewicz K, Wachełko O, Szpot P, Zawadzki M

45. 2022International Journal of Legal Medicine

    Blood concentrations of new synthetic opioids

    Adamowicz P, Nowak K

46. 2022Molecules

    Determination of Mifepristone (RU-486) and Its Metabolites in Maternal Blood Sample after Pharmacological Abortion

    Szpot P, Wachełko O, Jurek T, Zawadzki M

47. 2022Toxics

    Diclofenac Concentrations in Post-Mortem Specimens-Distribution, Case Reports, and Validated Method (UHPLC-QqQ-MS/MS) for Its Determination

    Szpot P, Wachełko O, Zawadzki M

48. 2022Molecules

    Forensic Toxicological Aspects of Misoprostol Use in Pharmacological Abortions

    Szpot P, Wachełko O, Zawadzki M

49. 2022Journal of Forensic and Legal Medicine

    Severe poisoning after smoking a mixture of 4-fluoroisobutyryl fentanyl (4-FiBF) and alpha-pyrolidinoisohexaphenone (α-PiHP)

    Zawadzki M, Wachełko O, Tusiewicz K, Szpot P

50. 2022Archiwum Medycyny Sądowej i Kryminologii

    Simultaneous poisoning of 48 birds of prey - bendiocarb determination with the use of UHPLC-ESI-MS/MS method in fatal case from Eastern Europe

    Chłopaś-Konowałek A, Zawadzki M, Kurach Ł, Wachełko O, Ciaputa R, Tusiewicz K, Szpot P

51. 2022Journal of Forensic Sciences

    The dark side of social media: Two deaths related with chloroform intoxication

    Tusiewicz K, Wachełko O, Zawadzki M, Chłopaś-Konowałek A, Jurek T, Kawecki J, Szpot P

52. 2022Toxics

    Toxicological Aspects of Methotrexate Intoxication: Concentrations in Postmortem Biological Samples and Autopsy Findings

    Szpot P, Wachełko O, Zawadzki M

53. 2021Scientific Reports

    A novel procedure for stabilization of azide in biological samples and method for its determination (HS-GC-FID/FID)

    Wachełko O, Zawadzki M, Szpot P

54. 2021Journal of Pharmaceutical and Biomedical Analysis

    A novel simple and precise method for the determination of azide impurity in sartans using headspace gas chromatography with two dissimilar capillary columns and two flame ionization detectors (HS-GC-FID/FID)

    Wachełko O, Szpot P, Zawadzki M

55. 2021Journal of Forensic and Legal Medicine

    Acute intranasal intoxication with mercuric chloride taken accidently instead of cocaine - A case report

    Magdalan J, Sozański T, Nowak K, Zawadzki M

56. 2021Burns

    Analgesic efficacy of sufentanil in dressings after surgical treatment of burn wounds

    Kowalski G, Zawadzki M, Leppert W, Szpot P, Siczek M, Słowiński K, Sobieszczańska M, Gawłowska A, Wieczorowska-Tobis K

57. 2021Journal of Chromatography B

    Application of ultra-sensitive GC-QqQ-MS/MS (MRM) method for the determination of diclofenac in whole blood samples without derivatization

    Szpot P, Wachełko O, Zawadzki M

58. 2021Behavioural Brain Research

    CE-123, a novel dopamine transporter inhibitor, attenuates locomotor hyperactivity and improves cognitive functions in rat model of fetal alcohol spectrum disorders

    Gibula-Tarlowska E, Korz V, Lopatynska-Mazurek M, Chlopas-Konowalek A, Grochecki P, Kalaba P, Dragacevic V, Kotlinski R, Kujawski R, Szulc M, Czora-Poczwardowska K, Mikolajczak PL, Lubec G, Kotlinska JH

59. 2021Journal of Analytical Toxicology

    Detection of Drugs in Postmortem Specimens of Blood, Vitreous Humor and Bone Marrow Aspirate

    Iskierka M, Zawadzki M, Szpot P, Jurek T

60. 2021Scientific Reports

    Etazene induces developmental toxicity in vivo Danio rerio and in silico studies of new synthetic opioid derivative

    Kurach Ł, Chłopaś-Konowałek A, Budzyńska B, Zawadzki M, Szpot P, Boguszewska-Czubara A

61. 2021Journal of Analytical Toxicology

    Old Poison, New Problem: Cyanide Fatal Intoxications Associated with Internet Shopping

    Wachełko O, Chłopaś-Konowałek A, Zawadzki M, Szpot P

62. 2021Science of the Total Environment

    Photochemical transformation of fentanyl under the simulated solar radiation - Enhancement of the process by heterogeneous photocatalysis and in silico analysis of toxicity

    Trawiński J, Szpot P, Zawadzki M, Skibiński R

63. 2021Journal of Forensic Sciences

    Quantification of methadone and its metabolites: EDDP and EMDP determined in autopsy cases using LC-MS/MS

    Nowak K, Szpot P, Jurek T, Zawadzki M

64. 2021Journal of Analytical Toxicology

    Rapid Determination of Sufentanil in Human Plasma by UHPLC-QqQ-MS-MS

    Zawadzki M, Kowalski G, Chłopaś-Konowałek A, Siczek M, Sobieszczańska M, Leppert W, Wieczorowska-Tobis K, Szpot P

65. 2021Food Chemistry

    The application of headspace gas chromatographic method for the determination of ethyl alcohol in craft beers, wines and soft drinks

    Wachełko O, Szpot P, Zawadzki M

66. 2020Talanta

    Fast and efficient analyses of the post-mortem human blood and bone marrow using DI-SPME/LC-TOFMS method for forensic medicine purposes

    Majda A, Mrochem K, Wietecha-Posłuszny R, Zapotoczny S, Zawadzki M

67. 2020Diagnostics

    Postmortem Determination of Short-Term Markers of Hyperglycemia for the Purposes of Medicolegal Opinions

    Nowak K, Jurek T, Zawadzki M

68. 2020Journal of Forensic Sciences

    The Stability of 4-Chloromethcathinone in Blood and Vitreous Humor

    Nowak K, Szpot P, Zawadzki M

69. 2019Journal of Forensic and Legal Medicine

    Comparison of post-mortem ethanol level in blood and bone marrow

    Iskierka M, Zawadzki M, Szpot P, Jurek T

70. 2019Anti-Cancer Drugs

    Fatal iatrogenic vinorelbine poisoning: a case report

    Zawadzki M, Magdalan J, Szpot P

71. 2019Talanta

    Postmortem analysis of human bone marrow aspirate - Quantitative determination of SSRI and SNRI drugs

    Snamina M, Wietecha-Posłuszny R, Zawadzki M

72. 2019Forensic Toxicology

    Unstability of 4-CMC in human serum specimen

    Nowak K, Szpot P, Zawadzki M

73. 2018Journal of Chromatography B

    Fragmentation patterns involving ammonium adduct fragment ions: A comparison of the determination of metaldehyde in human blood by HPLC-QqQ-MS/MS and UHPLC-Q-TOF-MS

    Szpot P, Buszewicz G, Jurek T, Teresiński G

74. 2018Acta Veterinaria Scandinavica

    Marijuana intoxication in a cat

    Janeczek A, Zawadzki M, Szpot P, Niedzwiedz A

75. 2018BMC Veterinary Research

    The detection of capsaicin and dihydrocapsaicin in horse serum following long-term local administration

    Zak A, Siwinska N, Slowikowska M, Borowicz H, Szpot P, Zawadzki M, Niedzwiedz A

76. 2017Journal of Chromatography B

    Human bone marrow as a tissue in post-mortem identification and determination of psychoactive Substances-Screening methodology

    Wietecha-Posłuszny R, Lendor S, Garnysz M, Zawadzki M, Kościelniak P

77. 2017Forensic Science, Medicine and Pathology

    Nonfatal and fatal intoxications with pure caffeine - report of three different cases

    Magdalan J, Zawadzki M, Skowronek R, Czuba M, Porębska B, Sozański T, Szpot P

78. 2016Forensic Toxicology

    Application of high-resolution mass spectrometry to determination of baclofen in a case of fatal intoxication

    Szpot P, Chłopaś A, Buszewicz G, Teresiński G

79. 2015Acta Pharmaceutica

    Determination of ramipril in human plasma and its fragmentation by UPLC-Q-TOF-MS with positive electrospray ionization

    Szpot P, Buszewicz G

80. 2014Pharmacological Reports

    Vague effects of chronic topiramate administration on maximal electroshock-induced seizures in mice

    Banach M, Szpot P, Buszewicz G, Borowicz KK

81. 2013Forensic Science International

    Suicidal overdose with relapsing clomipramine concentrations due to a large gastric pharmacobezoar

    Magdalan J, Zawadzki M, Słoka T, Sozański T

82. 2011Human & Experimental Toxicology

    Fulminant hepatic failure in woman with iron and non-steroidal anti-inflammatory drug intoxication

    Magdalan J, Zawadzki M, Sozanski T

83. 2010Przegląd Lekarski

    Fatal methanol poisoning complicated with acute coronary syndrome—a case report

    Magdalan J, Zawadzki M, Maksymowicz K

84. 2009Human & Experimental Toxicology

    Fatal intoxication with hydrocarbons in deltamethrin preparation

    Magdalan J, Zawadzki M, Merwid-Lad A

85. 2008Medycyna Pracy

    Modification of cardiovascular system in animals subjected to intoxication with manganese compounds

    Zawadzki M, Gać P, Poreba R, Andrzejak R

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